Platelet Activation Inhibitory Signaling
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Integrin alpha 2b beta 3
GPVI
CLEC-2
GPVI
CLEC-2
Integrin alpha 2b beta 3
GPVI
CLEC-2
GPVI
CLEC-2
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Src
Src
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Csk
Csk
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Lyn
Lyn
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Fyn
Fyn
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SHIP
SHIP
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CD31/
PECAM-1
PECAM-1
CD31/
PECAM-1
PECAM-1
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G6b
G6b
Shp1,2
Shp1,2
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PI 3-Kinase
PI 3-Kinase
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PLC-gamma
PLC-gamma
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alpha-2 Adrenergic R
alpha-2A Adrenergic R/ADRA2A
alpha-2B Adrenergic R/ADRA2B
alpha-2C Adrenergic R/ADRA2C
Adrenergic alpha-2 Receptor Agonists
Adrenergic alpha-2 Receptor Antagonists
Adrenergic alpha-2 Receptor Ligand Sets
Adrenergic alpha-2 Receptor Ligands
Adrenergic Receptor Ligand Sets
Additional Adrenergic Receptor-related Compounds
Adrenergic Related Compound Inhibitors
P2Y12
P2Y12/P2RY12
P2Y Receptor Agonists
P2Y Receptor Antagonists
PTGER3
PTGER3
Prostanoid Receptor Agonists
Prostanoid Receptor Antagonists
Additional Prostanoid Receptor Compounds
alpha-2A Adrenergic R/ADRA2A
alpha-2B Adrenergic R/ADRA2B
alpha-2C Adrenergic R/ADRA2C
Adrenergic alpha-2 Receptor Agonists
Adrenergic alpha-2 Receptor Antagonists
Adrenergic alpha-2 Receptor Ligand Sets
Adrenergic alpha-2 Receptor Ligands
Adrenergic Receptor Ligand Sets
Additional Adrenergic Receptor-related Compounds
Adrenergic Related Compound Inhibitors
P2Y12
P2Y12/P2RY12
P2Y Receptor Agonists
P2Y Receptor Antagonists
PTGER3
PTGER3
Prostanoid Receptor Agonists
Prostanoid Receptor Antagonists
Additional Prostanoid Receptor Compounds
alpha-2 Adrenergic R
P2Y12
PTGER3
P2Y12
PTGER3
alpha-2 Adrenergic R
P2Y12
PTGER3
P2Y12
PTGER3
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alpha-2 Adrenergic R
alpha-2A Adrenergic R/ADRA2A
alpha-2B Adrenergic R/ADRA2B
alpha-2C Adrenergic R/ADRA2C
Adrenergic alpha-2 Receptor Agonists
Adrenergic alpha-2 Receptor Antagonists
Adrenergic alpha-2 Receptor Ligand Sets
Adrenergic alpha-2 Receptor Ligands
Adrenergic Receptor Ligand Sets
Additional Adrenergic Receptor-related Compounds
Adrenergic Related Compound Inhibitors
P2Y12
P2Y12/P2RY12
P2Y Receptor Agonists
P2Y Receptor Antagonists
PTGER3
PTGER3
Prostanoid Receptor Agonists
Prostanoid Receptor Antagonists
Additional Prostanoid Receptor Compounds
alpha-2A Adrenergic R/ADRA2A
alpha-2B Adrenergic R/ADRA2B
alpha-2C Adrenergic R/ADRA2C
Adrenergic alpha-2 Receptor Agonists
Adrenergic alpha-2 Receptor Antagonists
Adrenergic alpha-2 Receptor Ligand Sets
Adrenergic alpha-2 Receptor Ligands
Adrenergic Receptor Ligand Sets
Additional Adrenergic Receptor-related Compounds
Adrenergic Related Compound Inhibitors
P2Y12
P2Y12/P2RY12
P2Y Receptor Agonists
P2Y Receptor Antagonists
PTGER3
PTGER3
Prostanoid Receptor Agonists
Prostanoid Receptor Antagonists
Additional Prostanoid Receptor Compounds
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G alpha i
G alpha i
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PTGER2,4
PTGIR
Adenosine A2a,A2b R
VIP R1/VPAC1
PTGIR
Adenosine A2a,A2b R
VIP R1/VPAC1
PTGER2,4
PTGIR
Adenosine A2a,A2b R
VIP R1/VPAC1
PTGIR
Adenosine A2a,A2b R
VIP R1/VPAC1
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PTGER2,4
PTGER2
PTGER4/EP4
Prostanoid Receptor Agonists
Prostanoid Receptor Antagonists
Additional Prostanoid Receptor Compounds
PTGIR
PTGIR
Prostanoid Receptor Agonists
Prostanoid Receptor Antagonists
Additional Prostanoid Receptor Compounds
Prostacyclin
Adenosine A2a,A2b R
Adenosine A2a R
Adenosine A2a Receptor Agonists
Adenosine A2a Receptor Antagonists
Adenosine A2b R
Adenosine A2b Receptor Agonists
Adenosine A2b Receptor Antagonists
Non-selective Adenosine Receptor Agonists
Non-selective Adenosine Receptor Antagonists
Other Adenosine Inhibitors
Additional Adenosine Products
AVIP R1/VPAC1
VIP R1/VPAC1
VIP Receptor Agonists
VIP Receptor Antagonists
PTGER2
PTGER4/EP4
Prostanoid Receptor Agonists
Prostanoid Receptor Antagonists
Additional Prostanoid Receptor Compounds
PTGIR
PTGIR
Prostanoid Receptor Agonists
Prostanoid Receptor Antagonists
Additional Prostanoid Receptor Compounds
Prostacyclin
Adenosine A2a,A2b R
Adenosine A2a R
Adenosine A2a Receptor Agonists
Adenosine A2a Receptor Antagonists
Adenosine A2b R
Adenosine A2b Receptor Agonists
Adenosine A2b Receptor Antagonists
Non-selective Adenosine Receptor Agonists
Non-selective Adenosine Receptor Antagonists
Other Adenosine Inhibitors
Additional Adenosine Products
AVIP R1/VPAC1
VIP R1/VPAC1
VIP Receptor Agonists
VIP Receptor Antagonists
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PTGER2,4
PTGER2
PTGER4/EP4
Prostanoid Receptor Agonists
Prostanoid Receptor Antagonists
Additional Prostanoid Receptor Compounds
PTGIR
PTGIR
Prostanoid Receptor Agonists
Prostanoid Receptor Antagonists
Additional Prostanoid Receptor Compounds
Prostacyclin
Adenosine A2a,A2b R
Adenosine A2a R
Adenosine A2a Receptor Agonists
Adenosine A2a Receptor Antagonists
Adenosine A2b R
Adenosine A2b Receptor Agonists
Adenosine A2b Receptor Antagonists
Non-selective Adenosine Receptor Agonists
Non-selective Adenosine Receptor Antagonists
Other Adenosine Inhibitors
Additional Adenosine Products
AVIP R1/VPAC1
VIP R1/VPAC1
VIP Receptor Agonists
VIP Receptor Antagonists
PTGER2
PTGER4/EP4
Prostanoid Receptor Agonists
Prostanoid Receptor Antagonists
Additional Prostanoid Receptor Compounds
PTGIR
PTGIR
Prostanoid Receptor Agonists
Prostanoid Receptor Antagonists
Additional Prostanoid Receptor Compounds
Prostacyclin
Adenosine A2a,A2b R
Adenosine A2a R
Adenosine A2a Receptor Agonists
Adenosine A2a Receptor Antagonists
Adenosine A2b R
Adenosine A2b Receptor Agonists
Adenosine A2b Receptor Antagonists
Non-selective Adenosine Receptor Agonists
Non-selective Adenosine Receptor Antagonists
Other Adenosine Inhibitors
Additional Adenosine Products
AVIP R1/VPAC1
VIP R1/VPAC1
VIP Receptor Agonists
VIP Receptor Antagonists
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G alpha s
G alpha s
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PTGER3
PTGER3
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G alpha z
G alpha z
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Adenylyl Cyclase
Adenylyl Cyclase
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cAMP
cAMP
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AMP
AMP
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PKA
PKA
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Phosphodiesterase 2,3
Phosphodiesterase 2,3
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Caldesmon
Caldesmon
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Filamin A
Filamin A
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G alpha 13
G alpha 13
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GPIb
GPIb
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HSP27
HSP27
IP3 Receptor
IP3 Receptor
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LASP
LASP
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MAPK
MAPK
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Phosphodiesterase 3A
Phosphodiesterase 3A
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Rap1
Rap1
Rap1GAP2
Rap1GAP2
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TRPC6
TRPC6
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VASP
VASP
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Nitric Oxide
Nitric Oxide
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L-Arginine
L-Arginine
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eNOS
eNOS
Citrulline
Citrulline
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Nitric Oxide
Nitric Oxide
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Soluble
Guanylyl
Cyclase
Guanylyl
Cyclase
Soluble
Guanylyl
Cyclase
Guanylyl
Cyclase
cGMP
cGMP
GMP
GMP
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Phosphodiesterase 5A
Phosphodiesterase 5A
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PKG
PKG
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HSP27
HSP27
IP3 Receptor
IP3 Receptor
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LASP
LASP
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Myosin Light
Chain Kinase
Chain Kinase
Myosin Light
Chain Kinase
Chain Kinase
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MAPK
MAPK
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PI 3-Kinase
PI 3-Kinase
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Phosphodiesterase 5A
Phosphodiesterase 5A
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Rap1
Rap1
Rap1GAP2
Rap1GAP2
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Thromboxane A2 R
Thromboxane A2 R
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TRPC6
TRPC6
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VASP
VASP
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Inhibition of
Inhibition of
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Granule Release
Granule Release
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Calcium Release
Calcium Release
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Integrin Activation
Integrin Activation
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Overview of Inhibitory Signaling in Platelets
Unrestricted platelet activation can lead to life threatening thrombosis. In order to maintain control of this process, multiple steps in the platelet activation are regulated by cell surface receptors that block activation signals and by receptors that induce both activating and inhibitory signaling. Healthy vascular endothelial cells release nitric oxide and prostaglandin I2 (prostacyclin) into the blood where they maintain platelet quiescence by blocking granule release and integrin activation.
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